新生黏附位点的力调节理论。
Theory of force regulation by nascent adhesion sites.
作者信息
Bruinsma Robijn
机构信息
Department of Physics and Astronomy, University of California at Los Angeles, USA.
出版信息
Biophys J. 2005 Jul;89(1):87-94. doi: 10.1529/biophysj.104.048280. Epub 2005 Apr 22.
Abstract
The mechanical coupling of a cell with the extracellular matrix relies on adhesion sites, clusters of membrane-associated proteins that communicate forces generated along the F-Actin filaments of the cytoskeleton to connecting tissue. Nascent adhesion sites have been shown to regulate these forces in response to tissue rigidity. Force-regulation by substrate rigidity of adhesion sites with fixed area is not possible for stationary adhesion sites, according to elasticity theory. A simple model is presented to describe force regulation by dynamical adhesion sites.
摘要
细胞与细胞外基质的机械耦合依赖于黏附位点，即膜相关蛋白簇，这些蛋白簇将沿细胞骨架的F-肌动蛋白丝产生的力传递到连接组织。已表明新生黏附位点可根据组织硬度调节这些力。根据弹性理论，对于固定面积的静止黏附位点，不可能通过底物硬度来调节力。本文提出了一个简单模型来描述动态黏附位点的力调节。
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本文引用的文献
1
Talin: an emerging focal point of adhesion dynamics.
Curr Opin Cell Biol. 2004 Feb;16(1):94-8. doi: 10.1016/j.ceb.2003.11.007.
2
Integrin activation.
J Cell Sci. 2004 Feb 15;117(Pt 5):657-66. doi: 10.1242/jcs.01014.
3
Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin.
Nature. 2003 Jul 17;424(6946):334-7. doi: 10.1038/nature01805.
4
Cells lying on a bed of microneedles: an approach to isolate mechanical force.
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1484-9. doi: 10.1073/pnas.0235407100. Epub 2003 Jan 27.
5
The relationship between force and focal complex development.
J Cell Biol. 2002 Nov 25;159(4):695-705. doi: 10.1083/jcb.200204153.
6
Global conformational rearrangements in integrin extracellular domains in outside-in and inside-out signaling.
Cell. 2002 Sep 6;110(5):599-11. doi: 10.1016/s0092-8674(02)00935-2.
7
Assembly and mechanosensory function of focal contacts.
Curr Opin Cell Biol. 2001 Oct;13(5):584-92. doi: 10.1016/s0955-0674(00)00255-6.
8
Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism.
J Cell Biol. 2001 Jun 11;153(6):1175-86. doi: 10.1083/jcb.153.6.1175.
9
Characterization of collagen gel solutions and collagen matrices for cell culture.
Biomaterials. 2001 Jul;22(13):1713-9. doi: 10.1016/s0142-9612(00)00315-x.
10
Probing the relation between force--lifetime--and chemistry in single molecular bonds.
Annu Rev Biophys Biomol Struct. 2001;30:105-28. doi: 10.1146/annurev.biophys.30.1.105.
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