Mori Ryoko, Matsushima Satoko, Honda Tetsuya, Horiguchi Yuji, Imamura Sadao
Department of Dermatology, Osaka Red Cross Hospital, Osaka, Japan.
J Dermatol. 2005 Mar;32(3):189-92. doi: 10.1111/j.1346-8138.2005.tb00743.x.
A 62-year-old Japanese male developed acneiform papules on the face in November of 2002. The eruptions progressed to exudative erythema with central necrosis, and then to thick-crusted superficial abscesses in a short period. The shallow ulcers exposed by removal of the crusts and abscesses immediately re-epithelized without leaving scars. The histology of the eruption was a dense infiltration of neutrophils associated with granulomatous changes in the upper to middle dermis. Histology of the tiny white particles in the abscess showed an irregularly proliferated mass of keratinocytes including accumulated neutrophils. The skin lesions resisted intravenous injection of antibiotics but responded to systemic administration of a corticosteroid agent. Colchicine did not work well, but the additional administration of etretinate was effective. The patient is currently receiving combined therapy with prednisolone and etretinate, but eruptions are still episodically observed. We diagnosed this case as an unusual male case of rosacea fulminans.
一名62岁的日本男性于2002年11月面部出现痤疮样丘疹。皮疹进展为伴有中央坏死的渗出性红斑,随后在短时间内发展为厚痂性浅表脓肿。去除痂皮和脓肿后暴露的浅表溃疡立即重新上皮化,未留下疤痕。皮疹的组织学表现为中性粒细胞密集浸润,伴有真皮上部至中部的肉芽肿性改变。脓肿中微小白色颗粒的组织学表现为角质形成细胞不规则增生,包括聚集的中性粒细胞。皮肤病变对抗生素静脉注射无效,但对全身性皮质类固醇药物治疗有反应。秋水仙碱效果不佳,但联合使用依曲替酯有效。该患者目前正在接受泼尼松龙和依曲替酯的联合治疗,但仍有皮疹发作。我们将该病例诊断为暴发性酒渣鼻的罕见男性病例。