异金属Ti-Ga-Salen体系催化内消旋环氧化合物与ArSeH的对映选择性开环反应。
Enantioselective ring-opening reaction of meso-epoxides with ArSeH catalyzed by heterometallic Ti-Ga-Salen system.
作者信息
Yang Minghua, Zhu Chengjian, Yuan Fang, Huang Yijun, Pan Yi
机构信息
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, China.
出版信息
Org Lett. 2005 May 12;7(10):1927-30. doi: 10.1021/ol0503034.
PMID:15876021
Abstract
The first example of enantioselective ring-opening reaction of meso-epoxides with aryl selenols to give optically active beta-arylseleno alcohol in up to 97% ee was realized, using a chiral Ti-Ga-Salen heterometallic catalyst. A strong synergistic effect of different Lewis acids in the system was exhibited in the catalytic process.
摘要
使用手性Ti-Ga-Salen异金属催化剂，实现了内消旋环氧化合物与芳基硒醇的对映选择性开环反应，以高达97%的对映体过量得到光学活性的β-芳基硒醇。在催化过程中，体系中不同路易斯酸表现出强烈的协同效应。
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