Lauro A, Hamel C, Cirocchi R, Alonso-Poza A, Gervaz P, Doria C, Gruttadauria S, Giustozzi G, Wexner S D
Department of Colorectal Surgery, Cleveland Clinic Florida, Fort Lauderdale, USA.
Minerva Chir. 2004 Dec;59(6):537-45.
Several studies have demonstrated the feasibility and safety of laparoscopic surgery for Crohn's disease. A trend towards less morbidity as compared to laparotomy has been suggested. However, problems noted early in the experience may have prevented the optimal benefit from having been conferred. Accordingly, the aim of this study was to evaluate perioperatively those patients.
All 51 patients with Crohn's disease who underwent an intestinal resection at Cleveland Clinic Florida between January 1997 and December 1998 were analyzed.
Seventeen patients underwent laparoscopic treatment: there were no significant differences between the 2 groups as to age, gender, incidences of comorbidity, prior laparotomy, or the use of anti-inflammatory and immunosuppressive agents. Similarly, there were no significant differences between the 2 groups as to either surgical indication, intraoperative findings, or procedure performed. Moreover, there were no significant differences concerning total anesthetic time or surgical operative time, the incidence of intraoperative morbidity or need for enterolysis or stoma construction, use of intraoperative endoscopy, or need for transfusion. Significant differences were noted in the duration of patient controlled analgesic usage (3.1 days in the laparoscopic group vs 3.9 days, respectively; p = 0.03), the incidence of postoperative morbidity (7/17 patients in the laparoscopic group vs 27/34 patients: p = 0.01), and length of hospital stay (6.4 days in the laparoscopic group vs 9.6 days, respectively; p = 0.05).
In this retrospective cohort comparative study, laparoscopic intestinal resection for Crohn's disease, when compared to laparotomy, was associated with a short duration of patient controlled analgesic usage, a lower incidence of postoperative morbidity and a shorter hospital stay, without significantly increased operative time.
多项研究已证实腹腔镜手术治疗克罗恩病的可行性和安全性。与开腹手术相比,有研究表明腹腔镜手术的发病率有降低趋势。然而,早期经验中发现的问题可能阻碍了其获得最佳疗效。因此,本研究旨在对这些患者进行围手术期评估。
分析了1997年1月至1998年12月在佛罗里达克利夫兰诊所接受肠道切除术的51例克罗恩病患者。
17例患者接受了腹腔镜治疗:两组在年龄、性别、合并症发生率、既往开腹手术史或抗炎及免疫抑制剂使用方面无显著差异。同样,两组在手术指征、术中发现或实施的手术操作方面也无显著差异。此外,在总麻醉时间或手术操作时间、术中发病率或肠粘连松解术或造口术的需求、术中内镜的使用或输血需求方面也无显著差异。在患者自控镇痛使用时间(腹腔镜组分别为3.1天,开腹组为3.9天;p = 0.03)、术后发病率(腹腔镜组7/17例患者,开腹组27/34例患者;p = 0.01)和住院时间(腹腔镜组分别为6.4天,开腹组为9.6天;p = 0.05)方面存在显著差异。
在这项回顾性队列比较研究中,与开腹手术相比,腹腔镜下克罗恩病肠切除术患者自控镇痛使用时间短、术后发病率低、住院时间短,且手术时间无显著增加。