帕金森病中，丘脑刺激对侧的单侧丘脑底核深部脑刺激。

Unilateral subthalamic nucleus deep brain stimulation contralateral to thalamic stimulation in Parkinson disease.

作者信息

Samii Ali, Slimp Jefferson C, Goodkin Robert

机构信息

VAPSHCS, Department of Neurology, University of Washington School of Medicine, Mailstop 127, 1660 S. Columbian Way, Seattle, WA 98108, USA.

出版信息

Parkinsonism Relat Disord. 2005 Jun;11(4):257-8. doi: 10.1016/j.parkreldis.2004.10.009. Epub 2005 Feb 8.

DOI:10.1016/j.parkreldis.2004.10.009

PMID:15878588

Abstract

The effects of unilateral subthalamic nucleus (STN) stimulation contralateral to thalamic stimulation in Parkinson disease (PD) have not been previously reported. We are reporting a patient who developed left arm tremor in 1994, at age 62, as her first PD symptom. She underwent right thalamic DBS surgery in 1999 that resulted in complete resolution of left arm tremor. Her PD symptoms progressed and she developed severe motor fluctuations and disabling dyskinesias. In 2003, she underwent left STN electrode implantation. Left STN stimulation improved contralateral motor scores in the medication OFF state, and allowed for reduced medication doses and less dyskinesia. However, there was no significant improvement in activities of daily living (ADL), motor scores in the medication ON state, gait, or postural stability.

摘要

帕金森病（PD）中，丘脑刺激对侧的单侧丘脑底核（STN）刺激的效果此前尚未见报道。我们报告了一名患者，她于1994年62岁时出现左臂震颤，这是她的首个帕金森病症状。1999年她接受了右侧丘脑深部脑刺激（DBS）手术，术后左臂震颤完全消失。她的帕金森病症状继续进展，出现了严重的运动波动和致残性异动症。2003年，她接受了左侧STN电极植入。左侧STN刺激改善了未用药状态下对侧的运动评分，还能减少药物剂量并减轻异动症。然而，日常生活活动能力（ADL）、用药状态下的运动评分、步态或姿势稳定性均无显著改善。