类圆线虫重度感染与低丙种球蛋白血症
Strongyloides hyperinfection and hypogammaglobulinemia.
作者信息
Seet Raymond C S, Lau Lee Gong, Tambyah Paul Ananth
机构信息
Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074.
出版信息
Clin Diagn Lab Immunol. 2005 May;12(5):680-2. doi: 10.1128/CDLI.12.5.680-682.2005.
Abstract
We report strongyloides hyperinfection in two patients with generalized hypogammaglobulinemia from multiple myeloma and nephrotic syndrome, despite a significant strongyloides-specific immunoglobulin G (IgG) response. In contrast to reports on animals, where human IgG was shown to be a protective antibody, our observation suggests that in humans, immunity to the infective-stage larvae is not protective against the autoinfective larvae, which are the causative agents of strongyloides hyperinfection.
摘要
我们报告了两例分别患有多发性骨髓瘤和肾病综合征所致的全身性低丙种球蛋白血症患者发生的类圆线虫高度感染，尽管患者对类圆线虫有显著的特异性免疫球蛋白G（IgG）反应。与关于动物的报道相反，在动物研究中人类IgG被证明是一种保护性抗体，而我们的观察结果表明，在人类中，针对感染期幼虫的免疫力并不能抵御自身感染性幼虫，而自身感染性幼虫正是类圆线虫高度感染的致病因素。
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