Mitsuyama Keiichi
Second Department of Medicine, Kurume University School of Medicine.
Nihon Rinsho. 2005 May;63(5):850-8.
Although the causes of inflammatory bowel disease including ulcerative colitis and Crohn's disease remain incompletely understood, increasing evidence implicates intestinal microflora in the pathogenesis of this disorder. Therefore, modulation of microflora with probiotics or prebiotics may offer a plausible therapeutic approach. While recent data support a potential therapeutic efficacy, such treatments need to be further assessed by large scale studies. A better understanding of the intestinal microflora and the mechanisms of their action may help us to develop more effective treatment for inflammatory bowel disease.
尽管包括溃疡性结肠炎和克罗恩病在内的炎症性肠病的病因仍未完全明确,但越来越多的证据表明肠道微生物群与这种疾病的发病机制有关。因此,用益生菌或益生元调节微生物群可能提供一种可行的治疗方法。虽然最近的数据支持潜在的治疗效果,但此类治疗需要通过大规模研究进一步评估。更好地了解肠道微生物群及其作用机制可能有助于我们开发出更有效的炎症性肠病治疗方法。