一种用于测定片剂中加替沙星的紫外分光光度法的开发与验证
Development and validation of an UV spectrophotometric method for determination of gatifloxacin in tablets.
作者信息
Salgado H R N, Oliveira C L C G
机构信息
Programa de Pós-graduação em Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, Araraquara SP, Brazil.
出版信息
Pharmazie. 2005 Apr;60(4):263-4.
A simple, sensitive and accurate spectrophotometric method was developed for the assay of gatifloxacin in raw material and tablets. Validation of the method yielded good results concerning range, linearity, precision and accuracy. The absorbance was measured at 287 nm for gatifloxacin tablet solutions. The linearity range was found to be 4.0-14.0 microg/mL for gatifloxacin. It was also found that the excipients in the commercial tablets did not interfere with the method.
建立了一种简单、灵敏且准确的分光光度法，用于测定原料和片剂中的加替沙星。该方法的验证在范围、线性、精密度和准确度方面均取得了良好结果。加替沙星片剂溶液在287 nm处测定吸光度。加替沙星的线性范围为4.0 - 14.0 μg/mL。还发现市售片剂中的辅料不干扰该方法。
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