脱氧核糖核苷激酶：两个酶家族催化相同的反应。

Deoxyribonucleoside kinases: two enzyme families catalyze the same reaction.

作者信息

Sandrini Michael P B, Piskur Jure

机构信息

Cell and Organism Biology, Lund University, Sölvegatan 35, SE-22732 Lund, Sweden.

出版信息

Trends Biochem Sci. 2005 May;30(5):225-8. doi: 10.1016/j.tibs.2005.03.003.

DOI:10.1016/j.tibs.2005.03.003

PMID:15896737

Abstract

Mammals have four deoxyribonucleoside kinases, the cytoplasmic (TK1) and mitochondrial (TK2) thymidine kinases, and the deoxycytidine (dCK) and deoxyguanosine (dGK) kinases, which salvage the precursors for nucleic acids synthesis. In addition to the native deoxyribonucleoside substrates, the kinases can phosphorylate and thereby activate a variety of anti-cancer and antiviral prodrugs. Recently, the crystal structure of human TK1 has been solved and has revealed that enzymes with fundamentally different origins and folds catalyze similar, crucial cellular reactions.

摘要

哺乳动物有四种脱氧核糖核苷激酶，即细胞质（TK1）和线粒体（TK2）胸苷激酶，以及脱氧胞苷激酶（dCK）和脱氧鸟苷激酶（dGK），它们可挽救核酸合成的前体。除了天然的脱氧核糖核苷底物外，这些激酶还能使多种抗癌和抗病毒前体药物磷酸化并激活。最近，人类TK1的晶体结构已被解析，结果显示，来源和折叠方式截然不同的酶催化着相似且关键的细胞反应。