乳糜泻患者的炎症性肠病
Inflammatory bowel disease in patients with celiac disease.
作者信息
Yang Alice, Chen Yu, Scherl Ellen, Neugut Alfred I, Bhagat Govind, Green Peter H R
机构信息
Department of Medicine, Pathology and Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, New York, USA.
出版信息
Inflamm Bowel Dis. 2005 Jun;11(6):528-32. doi: 10.1097/01.mib.0000161308.65951.db.
BACKGROUND
Several case reports and series report an association between celiac disease and inflammatory bowel disease (IBD); however, there is no current data assessing this association. We therefore studied the occurrence of these conditions in a cohort of patients with celiac disease seen at a referral center.
METHODS
A database of patients with celiac disease seen between 1981 and 2002 was analyzed. Only biopsy-proven adults were included. Patients who had endoscopic and pathologic evidence of IBD were identified, and their pathology was reviewed. Age- and sex-adjusted prevalence rate ratios were determined by comparing results with population-based prevalence data.
RESULTS
Among 455 patients with celiac disease, IBD was identified in 10 (5 had ulcerative colitis and 5 had Crohn's disease). This represented an age- and sex-adjusted prevalence rate ratio for ulcerative colitis of 3.56 (95% confidence interval, 1.48-8.56) and for Crohn's disease of 8.49 (95% confidence interval, 3.53-20.42).
CONCLUSION
Within our cohort of patients with celiac disease, IBD was significantly more common than in the general population.
背景
多项病例报告及系列研究报告了乳糜泻与炎症性肠病（IBD）之间的关联；然而，目前尚无评估此关联的数据。因此，我们对一家转诊中心的一组乳糜泻患者中这些疾病的发生情况进行了研究。
方法
分析了1981年至2002年间诊治的乳糜泻患者数据库。仅纳入经活检证实的成年患者。识别出有IBD内镜及病理证据的患者，并对其病理进行复查。通过将结果与基于人群的患病率数据进行比较，确定年龄和性别调整后的患病率比值。
结果
在455例乳糜泻患者中，确诊IBD的有10例（5例为溃疡性结肠炎，5例为克罗恩病）。这代表溃疡性结肠炎的年龄和性别调整患病率比值为3.56（95%置信区间，1.48 - 8.56），克罗恩病为8.49（95%置信区间，3.53 - 20.42）。
结论
在我们的乳糜泻患者队列中，IBD的发病率显著高于普通人群。
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