Ramprasath V R, Shanthi P, Sachdanandam P
Department of Medical Biochemistry, Dr A. L. Mudaliar Post-Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India.
Cell Biochem Funct. 2006 Jul-Aug;24(4):333-40. doi: 10.1002/cbf.1243.
Neutrophils play an important role in the pathogenesis of rheumatoid arthritis (RA) and various inflammatory conditions, by accumulation and liberation of active proteolytic enzymes. The effect of milk extract of Semecarpus anacardium Linn. nuts (SA) at a dosage of 150 mg kg(-1) body weight day(-1) for 14 days on adjuvant arthritis was studied to gain some insight into this intriguing disease in relation to neutrophil functions. The decreased phagocytic function of neutrophils (phagocytic index and avidity index) found in adjuvant arthritis was significantly increased by the administration of the drug SA. Increased levels of reactive oxygen species (superoxide radical, hydroxyl radical, H2O2 and myeloperoxidase), lysosomal enzymes (acid phosphatase and cathepsin D) and increased accumulation of neutrophils in the joints observed in adjuvant arthritic animals were reverted back to near normal levels by treatment with SA. The results of this study indicate that SA can be considered to be a good therapeutic agent for inflammation and arthritis.
中性粒细胞通过活性蛋白水解酶的积累和释放，在类风湿性关节炎（RA）和各种炎症性疾病的发病机制中发挥重要作用。研究了以150毫克每千克体重每天的剂量给予印度漆树果仁乳提取物（SA），连续14天对佐剂性关节炎的影响，以深入了解这种与中性粒细胞功能相关的有趣疾病。佐剂性关节炎中发现的中性粒细胞吞噬功能降低（吞噬指数和亲和力指数），通过给予药物SA得到显著提高。佐剂性关节炎动物关节中观察到的活性氧（超氧阴离子自由基、羟基自由基、过氧化氢和髓过氧化物酶）、溶酶体酶（酸性磷酸酶和组织蛋白酶D）水平升高以及中性粒细胞积累增加，经SA治疗后恢复到接近正常水平。本研究结果表明，SA可被认为是治疗炎症和关节炎的良好药物。
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