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良性阵发性位置性眩晕的长期预后及健康相关生活质量

Long-term outcome and health-related quality of life in benign paroxysmal positional vertigo.

作者信息

Lopez-Escamez Jose A, Gamiz Maria J, Fernandez-Perez Antonio, Gomez-Fiñana Manuel

机构信息

Otology and Neurotology Group CTS495 of the Department of Surgery, Hospital de Poniente, Almería, Spain.

出版信息

Eur Arch Otorhinolaryngol. 2005 Jun;262(6):507-11. doi: 10.1007/s00405-004-0841-x. Epub 2004 Nov 16.

Abstract

A prospective cohort study was designed to evaluate the long-term outcome and health-related quality of life (HRQoL) in patients with posterior canal benign paroxysmal positional vertigo (PC-BPPV) treated by the particle repositioning maneuver (PRM) in the outpatient clinic of a general community hospital. Fifty individuals with PC-BPPV were included, and 45 (90%) completed the study. The diagnosis was based on the history of short episodes of vertigo and a positional nystagmus during the Dix-Hallpike test (DHT). All patients were treated by a single PRM, and relapses were evaluated by DHT at 30, 180 and 360 days post-treatment; a new PRM was performed if the DHT was positive. The main outcome measures were: percentage of patients with a negative DHT after treatment, scores obtained on the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) and the Dizziness Handicap Inventory Short Form (DHI-S) before and 30, 180 and 360 days post-treatment. The DHT was found negative in 80% (40/50) of individuals at 30 days. Ten, seven and five patients presented a positive DHT at 30, 180 and 360 days, respectively. Persistent BPPV was observed in 5% (2/50) of patients at 360 days, despite repeated PRM. Relapses (DH+ after successful PRM) were observed in 7.5% (3/50) at 180 days and 360 days. Both questionnaires showed a reliability Cronbach's alpha >0.7. The average standardized score for each SF-36 scale was compared with the reference population normative data, showing differences with norms for all scales except for vitality. After PRM, patients improved their scores with both instruments, indicating a restoration of HRQoL at 30 days. Physical dimension scores of the SF-36 improved from day 30 to 360. DHI-S scores were statistically better after PRM (P < 0.001). Our results show that the effectiveness of PRM is 88% after 1 year of follow-up. Patients with BPPV experienced a decrease in HRQoL, which was restored after PRM. Although relapses were observed in 7.5% of individuals, they did not affect HRQoL.

摘要

一项前瞻性队列研究旨在评估在一家普通社区医院门诊接受颗粒复位法(PRM)治疗的后半规管良性阵发性位置性眩晕(PC-BPPV)患者的长期预后及健康相关生活质量(HRQoL)。纳入了50例PC-BPPV患者,45例(90%)完成了研究。诊断基于眩晕短发作病史及Dix-Hallpike试验(DHT)期间的位置性眼球震颤。所有患者均接受单次PRM治疗,并在治疗后30、180和360天通过DHT评估复发情况;若DHT为阳性,则进行新的PRM。主要结局指标为:治疗后DHT阴性的患者百分比、治疗前及治疗后30、180和360天在医学结局研究36项简短健康调查(SF-36)和头晕残障量表简表(DHI-S)上获得的分数。30天时,80%(40/50)的患者DHT为阴性。分别有10例、7例和5例患者在30、180和360天时DHT为阳性。尽管重复进行PRM,但在360天时仍有5%(2/50)的患者观察到持续性BPPV。在180天和360天时,7.5%(3/50)的患者观察到复发(PRM成功后DHT阳性)。两份问卷的Cronbach's alpha信度均>0.7。将每个SF-36量表的平均标准化分数与参考人群的标准数据进行比较,结果显示除活力外,所有量表的分数均与标准存在差异。PRM后,患者在两个量表上的分数均有所提高,表明在30天时HRQoL得到恢复。SF-36的身体维度分数从30天到360天有所改善。PRM后DHI-S分数在统计学上更好(P<0.001)。我们的结果表明,随访1年后PRM的有效率为88%。BPPV患者的HRQoL有所下降,PRM后得以恢复。尽管7.5%的个体观察到复发,但它们并未影响HRQoL。

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