鼓室内注射地塞米松治疗重度特发性突发性感音神经性听力损失
Intratympanic dexamethasone for profound idiopathic sudden sensorineural hearing loss.
作者信息
Battista Robert A
机构信息
Northwestern University Medical School, Chicago, Illinois, USA.
出版信息
Otolaryngol Head Neck Surg. 2005 Jun;132(6):902-5. doi: 10.1016/j.otohns.2005.01.024.
OBJECTIVES
To determine hearing recovery by using intratympanic dexamethasone for profound, idiopathic sudden sensorineural hearing loss (ISSNHL).
STUDY DESIGN AND SETTING
A prospective, clinical study was performed of 25 consecutive patients seen with profound ISSNHL. Patients received 4 intratympanic treatments of dexamethasone over the course of 2 weeks. Complete hearing recovery was defined as the final pure-tone average (PTA) within 10 dB of baseline. Partial recovery was defined as a final PTA with >/=50% hearing. The hearing in the contralateral ear was used as baseline.
RESULTS
The average time to treatment was 28 days. Two patients had significant hearing recovery, and 1 additional patient had partial recovery. The 2 patients with significant hearing recovery were treated within 9 days of onset of hearing loss.
CONCLUSIONS
By using the treatment protocol and definition of hearing recovery of this study, intratympanic dexamethasone does not result in significant hearing improvement for patients with profound ISSNHL. There is a possible trend for improved hearing results if intratympanic treatment is performed within 11 days of onset of hearing loss.
目的
通过鼓室内注射地塞米松治疗重度特发性突发性感音神经性听力损失（ISSNHL）来确定听力恢复情况。
研究设计与设置
对连续25例重度ISSNHL患者进行了一项前瞻性临床研究。患者在2周内接受4次鼓室内地塞米松治疗。完全听力恢复定义为最终纯音平均听阈（PTA）在基线±10dB以内。部分恢复定义为最终PTA听力改善≥50%。对侧耳听力作为基线。
结果
平均治疗时间为28天。2例患者听力显著恢复，另有1例患者部分恢复。2例听力显著恢复的患者在听力损失发作后9天内接受了治疗。
结论
按照本研究的治疗方案和听力恢复定义，鼓室内注射地塞米松对重度ISSNHL患者的听力改善不显著。如果在听力损失发作后11天内进行鼓室内治疗，可能存在听力改善的趋势。
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