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腰椎软骨母细胞瘤。两例报告并文献复习。

Chondroblastoma of the lumbar spine. Report of two cases and review of the literature.

作者信息

Vialle Raphaël, Feydy Antoine, Rillardon Ludovic, Tohme-Noun Carla, Anract Philippe, Colombat Magali, De Pinieux Gonzague, Drapé Jean-Luc, Guigui Pierre

机构信息

Department of Orthopedic Surgery, Beaujon Hospital, Clichy Cedex, France.

出版信息

J Neurosurg Spine. 2005 May;2(5):596-600. doi: 10.3171/spi.2005.2.5.0596.

Abstract

Chondroblastoma is a benign cartilaginous neoplasm that generally affects the appendicular skeleton. Twenty-six cases of spinal chondroblastoma have been reported in the past 50 years, only six of which were located in the lumbar region. The authors report two cases involving this exceptional location. In both patients, low-back pain, in the absence of radicular pain, was the presenting symptom. In both cases, plain radiography and computerized tomography scanning revealed an osteolytic lesion surrounded by marginal sclerosis. Magnetic resonance imaging allowed the authors to study the tumor's local extension. Examination of a percutaneous fluoroscopy-guided biopsy sample revealed the following typical histological features of chondroblastoma: chondroid tissue, focally alternating with cellular areas, and no nuclear atypia or pleomorphism. To reduce the risk of local recurrence, vertebrectomy and anterior-posterior fusion were performed in both cases. In one case, a structural lumbar scoliosis was corrected during the posterior procedure. There was no postoperative complication. No recurrence was observed during the 3- to 6-year follow-up period. The surgery-related results were deemed successful. Although exceptional, the diagnosis of chondroblastoma is possible in lesions involving the lumbar spine. Other spinal locations are described in the literature, and frequency of recurrence is stressed. A vertebrectomy is advised to reduce the risk of local recurrence.

摘要

软骨母细胞瘤是一种良性软骨肿瘤,通常累及四肢骨骼。在过去50年中,已有26例脊柱软骨母细胞瘤的报道,其中仅6例位于腰椎区域。作者报告了2例发生在这一特殊部位的病例。两名患者均以腰背痛为首发症状,无神经根性疼痛。两例患者的X线平片和计算机断层扫描均显示溶骨性病变,周边有骨质硬化。磁共振成像使作者能够研究肿瘤的局部扩展情况。经皮透视引导下活检样本检查显示出软骨母细胞瘤典型的组织学特征:软骨样组织,局部与细胞区域交替,无核异型性或多形性。为降低局部复发风险,两例患者均行椎体切除术及前后路融合术。其中1例患者在后路手术过程中矫正了结构性腰椎侧弯。术后无并发症。在3至6年的随访期内未观察到复发。手术相关结果被认为是成功的。尽管罕见,但在累及腰椎的病变中诊断软骨母细胞瘤是可能的。文献中还描述了其他脊柱部位的情况,并强调了复发频率。建议行椎体切除术以降低局部复发风险。

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