Berardi Domenico, Menchetti Marco, Cevenini Nadia, Scaini Sara, Versari Matteo, De Ronchi Diana
Institute of Psychiatry, Bologna University, Bologna, Italy.
Psychother Psychosom. 2005;74(4):225-30. doi: 10.1159/000085146.
Underrecognition and undertreatment of depression in primary care has been regarded as a major public health problem. In contrast, some studies found that among patients labeled as depressed by primary-care physicians (PCPs), a relevant proportion do not satisfy international diagnostic criteria for depression. The aims of this study are: (1) to assess disparity between PCP diagnosis and research diagnosis of depression; (2) to compare antidepressant treatment in concordant and discordant cases of depression.
Data are gathered from a national survey on depressive disorders in primary care, conducted with the collaboration of 191 PCPs. Three hundred and sixty-one PCP patients were evaluated, and their psychiatric diagnosis was established by the 'unaided' PCPs and by using a research interview for depression.
PCPs recognized 79.4% of cases of depression and prescribed antidepressants to 40.9% of them. Yet, 45.0% of patients labeled as depressed by the PCPs were not cases of depression according to ICD-10 criteria; 26.9% of false-positive cases received an antidepressant. Globally, 35% of antidepressants for 'depression' were prescribed to false-positive cases.
Underrecognition and undertreatment of depression in primary care seem to be less alarming. Conversely, PCP diagnoses of depression appear to be more inclusive than psychiatric diagnostic criteria. A possible consequence of this apparently more inclusive diagnostic threshold may be an excessive use of antidepressants. These changes require a corresponding change in research, toward efficacy and safety of the treatment of milder cases, and in education, toward the distinction between the management of mild and severe cases of depression.
基层医疗中抑郁症的识别不足和治疗不足一直被视为一个主要的公共卫生问题。相比之下,一些研究发现,在基层医疗医生(PCP)诊断为抑郁症的患者中,有相当一部分不符合抑郁症的国际诊断标准。本研究的目的是:(1)评估基层医疗医生对抑郁症的诊断与研究诊断之间的差异;(2)比较抑郁症诊断一致和不一致病例中的抗抑郁药治疗情况。
数据来自一项关于基层医疗中抑郁症的全国性调查,该调查由191名基层医疗医生合作开展。对361名基层医疗医生的患者进行了评估,他们的精神疾病诊断由“独立”的基层医疗医生以及通过抑郁症研究访谈来确定。
基层医疗医生识别出79.4%的抑郁症病例,并为其中40.9%的患者开了抗抑郁药。然而,根据国际疾病分类第10版(ICD - 10)标准,被基层医疗医生诊断为抑郁症的患者中有45.0%并非抑郁症病例;26.9%的假阳性病例接受了抗抑郁药治疗。总体而言,用于“抑郁症”的抗抑郁药中有35%被开给了假阳性病例。
基层医疗中抑郁症的识别不足和治疗不足似乎不那么令人担忧。相反,基层医疗医生对抑郁症的诊断似乎比精神科诊断标准更具包容性。这种明显更具包容性的诊断阈值可能导致抗抑郁药的过度使用。这些变化需要研究相应地转向对较轻病例治疗的疗效和安全性,以及教育方面转向区分轻度和重度抑郁症病例的管理。