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注意缺陷/多动障碍执行功能理论的效度:一项元分析综述

Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review.

作者信息

Willcutt Erik G, Doyle Alysa E, Nigg Joel T, Faraone Stephen V, Pennington Bruce F

机构信息

Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA.

出版信息

Biol Psychiatry. 2005 Jun 1;57(11):1336-46. doi: 10.1016/j.biopsych.2005.02.006.

Abstract

One of the most prominent neuropsychologic theories of attention-deficit/hyperactivity disorder (ADHD) suggests that its symptoms arise from a primary deficit in executive functions (EF), defined as neurocognitive processes that maintain an appropriate problem-solving set to attain a later goal. To examine the validity of the EF theory, we conducted a meta-analysis of 83 studies that administered EF measures to groups with ADHD (total N = 3734) and without ADHD (N = 2969). Groups with ADHD exhibited significant impairment on all EF tasks. Effect sizes for all measures fell in the medium range (.46-.69), but the strongest and most consistent effects were obtained on measures of response inhibition, vigilance, working memory, and planning. Weaknesses in EF were significant in both clinic-referred and community samples and were not explained by group differences in intelligence, academic achievement, or symptoms of other disorders. ADHD is associated with significant weaknesses in several key EF domains. However, moderate effect sizes and lack of universality of EF deficits among individuals with ADHD suggest that EF weaknesses are neither necessary nor sufficient to cause all cases of ADHD. Difficulties with EF appear to be one important component of the complex neuropsychology of ADHD.

摘要

注意力缺陷多动障碍(ADHD)最著名的神经心理学理论之一认为,其症状源于执行功能(EF)的原发性缺陷,执行功能被定义为维持适当的问题解决定势以实现后续目标的神经认知过程。为了检验执行功能理论的有效性,我们对83项研究进行了荟萃分析,这些研究对患有ADHD的组(总计N = 3734)和未患ADHD的组(N = 2969)进行了执行功能测量。患有ADHD的组在所有执行功能任务上均表现出显著损伤。所有测量的效应量都处于中等范围(0.46 - 0.69),但在反应抑制、警觉性、工作记忆和计划测量方面获得了最强且最一致的效应。执行功能缺陷在临床转诊样本和社区样本中均很显著,并且不能通过智力、学业成绩或其他障碍症状的组间差异来解释。ADHD与几个关键执行功能领域的显著缺陷相关。然而,中等效应量以及ADHD个体中执行功能缺陷缺乏普遍性表明,执行功能缺陷对于导致所有ADHD病例既非必要条件也非充分条件。执行功能方面的困难似乎是ADHD复杂神经心理学的一个重要组成部分。

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