严重急性呼吸综合征冠状病毒3a基因内的基因损伤
Genetic lesions within the 3a gene of SARS-CoV.
作者信息
Tan Timothy H P, Barkham Timothy, Fielding Burtram C, Chou Chih-Fong, Shen Shuo, Lim Seng Gee, Hong Wanjin, Tan Yee-Joo
机构信息
Institute of Molecular and Cell Biology, 61 Biopolis Drive, 138673, Singapore.
出版信息
Virol J. 2005 Jun 20;2:51. doi: 10.1186/1743-422X-2-51.
Abstract
A series of frameshift mutations within the 3a gene has been observed in culture-derived severe acute respiratory syndrome coronavirus (SARS-CoV). We report here that viral RNA from clinical samples obtained from SARS-CoV infected patients also contains a heterogeneous population of wild-type and mutant 3a transcripts.
摘要
在培养获得的严重急性呼吸综合征冠状病毒（SARS-CoV）中观察到3a基因内存在一系列移码突变。我们在此报告，从感染SARS-CoV的患者获得的临床样本中的病毒RNA也包含野生型和突变型3a转录本的异质群体。
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