硬皮多孔菌子实体的细胞毒性成分。

Cytotoxic constituents of the fruit body of Daedalea dickisii.

作者信息

Yoshikawa Kazuko, Kouso Kazuaki, Takahashi Jyoji, Matsuda Akiko, Okazoe Mina, Umeyama Akemi, Arihara Shigenobu

机构信息

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-Cho, Japan.

出版信息

J Nat Prod. 2005 Jun;68(6):911-4. doi: 10.1021/np058024c.

DOI:10.1021/np058024c

PMID:15974617

Abstract

Three new lanostane triterpenoids (1, 7, 8) and five new lanostane triterpene glucosides (2-6) have been isolated from the fruit bodies of Daedalea dickinsii. Their structures were established primarily by NMR experiments, and their biological activity against HL-60 and HCT-15 cell lines was investigated. Compounds 3-6 induced internucleosomal DNA fragmentation characteristic of apoptotic cell death in the HL-60 cell line.

摘要

从毛栓菌子实体中分离出三种新的羊毛甾烷三萜（1、7、8）和五种新的羊毛甾烷三萜糖苷（2 - 6）。它们的结构主要通过核磁共振实验确定，并研究了它们对HL - 60和HCT - 15细胞系的生物活性。化合物3 - 6在HL - 60细胞系中诱导出凋亡细胞死亡特征性的核小体间DNA片段化。