Nature's protection racket.
作者信息
Micklefield Jason
机构信息
School of Chemistry, University of Manchester, Sackville Street, PO Box 88, Manchester, M60 1QD, UK.
出版信息
Chem Biol. 2005 Jun;12(6):611-3. doi: 10.1016/j.chembiol.2005.06.002.
Abstract
(2S)-4-amino-2-hydroxybutyrate (AHBA) is a side chain that is important for the antibiotic activities of aminoglycosides. The elucidation of the biosynthetic pathway to AHBA, by Spencer et al. in this issue of Chemistry & Biology [1], reveals several surprises and will facilitate biosynthetic engineering of new improved aminoglycoside antibiotics.
摘要
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