Smith M D, Baeten D, Ulfgren A-K, McInnes I B, Fitzgerald O, Bresnihan B, Tak P P, Veale D
Rheumatology Research Unit, Repatriation General Hospital, Adelaide, South Australia.
Ann Rheum Dis. 2006 Jan;65(1):93-100. doi: 10.1136/ard.2005.036905. Epub 2005 Jun 23.
Changes in cellular infiltrate and expression of cytokines, chemokines, and cell adhesion molecules as a result of therapeutic interventions in rheumatoid arthritis can be demonstrated in the synovial membrane. However, before synovial tissue analysis can be used as an outcome measure in such studies, standardisation of the site and method of synovial tissue acquisition, methods of tissue processing, and appropriate methods of detection and measurement of cell lineage specific markers and relevant biological proteins is needed.
类风湿关节炎治疗干预导致的细胞浸润以及细胞因子、趋化因子和细胞黏附分子表达的变化,可在滑膜组织中得到证实。然而,在滑膜组织分析能够作为此类研究的一项结果指标之前,需要对滑膜组织获取的部位和方法、组织处理方法以及细胞谱系特异性标志物和相关生物蛋白的合适检测与测量方法进行标准化。