Ovarian function after radioiodine therapy in patients with thyroid cancer.
作者信息
Souza Rosário P W, Alvarenga Fagundes T, Villas-Boas Fagundes A S, Barroso A L, Lamego Rezende L, Lanza Padrão E, Guimarães V C, Horta A C, Franco M, Purisch S
机构信息
Nuclear Medicine and Endocrinology Service, Santa Casa de Belo Horizonte, Minas Gerais, Brazil.
出版信息
Exp Clin Endocrinol Diabetes. 2005 Jun;113(6):331-3. doi: 10.1055/s-2005-837666.
OBJECTIVE
To assess ovarian function in young women treated with radioiodine.
METHODS
The study was conducted on 50 women with thyroid carcinoma aged less than 40 years (mean, 29.8 years), with regular menstrual cycles and normal FSH levels prior to radioiodine therapy. FSH determination was repeated 6 and 12 months after radioiodine therapy (mean, 4.24 GBq iodine-131) and menstrual cycles were monitored during this period.
RESULTS
Twenty percent of the patients reported amenorrhea during the first year. FSH levels increased after 6 months (from 5.1 +/- 1.8 to 10.6 +/- 2.2 IU/l, p < 0.00 001) and 28 % of the patients showed elevated values, which had returned to normal by the end of the first year.
CONCLUSION
Radioiodine causes transitory alterations in ovarian function even in younger women and after a mean activity of 4.2 GBq (115 mCi).
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