Lee Ja Young, Kim Hak Yang, Kim Kyung Ho, Kim Seong Man, Jang Myoung Kuk, Park Joon Yong, Lee Jin Heon, Kim Jin-Ho, Yoo Jae Young
Division of Gastroenterology, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University Medical Center, 445, Kildong, Kangdong-gu, Seoul 134-701, South Korea.
Cancer Lett. 2005 Jul 28;225(2):207-14. doi: 10.1016/j.canlet.2004.11.028. Epub 2004 Dec 16.
We performed this study to determine the role of polymorphisms of the IL-10 and TNF-alpha promoter genes in the carcinogenesis/pathogenesis of gastric cancer (GC) and peptic ulcer diseases (PUD) in Korea. A total of 232 patients with gastric diseases and 120 healthy controls were included. Polymorphisms of IL-10-1082/-592 gene and TNF-A-308 gene were genotyped by PCR-RFLP. There were no differences in genotypes and allele frequencies of IL-10 and TNF-A polymorphism between study group with GC or PUD and control group. In addition, there were no differences in genotypic frequencies according to H. pylori infection status, location of GC, and histologic type of GC. In conclusion, IL-10-1082/-592 and TNF-A-308 genetic polymorphisms may not be the important contributors to GC in Korea.
我们开展这项研究，以确定白细胞介素-10（IL-10）和肿瘤坏死因子-α（TNF-α）启动子基因多态性在韩国胃癌（GC）和消化性溃疡疾病（PUD）的致癌作用/发病机制中的作用。共纳入了232例胃部疾病患者和120名健康对照者。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术对IL-10 -1082/-592基因和TNF-A -308基因的多态性进行基因分型。GC或PUD研究组与对照组之间，IL-10和TNF-A多态性的基因型及等位基因频率无差异。此外，根据幽门螺杆菌感染状况、GC的位置以及GC的组织学类型，基因型频率也无差异。总之，在韩国，IL-10 -1082/-592和TNF-A -308基因多态性可能并非GC的重要促成因素。
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