Scott J Anthony G, Mwarumba Salim, Ngetsa Caroline, Njenga Salome, Lowe Brett S, Slack Mary P E, Berkley James A, Mwangi Isaiah, Maitland Kathryn, English Mike, Marsh Kevin
Wellcome Trust/Kenya Medical Research Institute, Centre for Geographic Medicine Research--Coast, P.O. Box 230, Kilifi, Kenya.
Antimicrob Agents Chemother. 2005 Jul;49(7):3021-4. doi: 10.1128/AAC.49.7.3021-3024.2005.
Etest susceptibilities to amoxicillin, chloramphenicol, and trimethoprim-sulfamethoxazole of 240 invasive isolates of Haemophilus influenzae cultured from children in rural Kenya were 66%, 66%, and 38%, respectively. Resistance increased markedly over 9 years and was concentrated among serotype b isolates. In Africa, the increasing cost of treating resistant infections supports economic arguments for prevention through conjugate H. influenzae type b immunization.
对从肯尼亚农村儿童中培养出的240株侵袭性流感嗜血杆菌分离株进行的Etest药敏试验显示,其对阿莫西林、氯霉素和甲氧苄啶-磺胺甲恶唑的药敏率分别为66%、66%和38%。耐药性在9年中显著增加,且集中在b型血清型分离株中。在非洲,治疗耐药感染成本的增加支持了通过b型流感嗜血杆菌结合疫苗免疫进行预防的经济学论据。