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1994年至2002年期间,从肯尼亚基利菲一家医院收治的儿童中获得的流感嗜血杆菌侵袭性分离株的抗菌耐药性呈逐步上升趋势。

Progressive increase in antimicrobial resistance among invasive isolates of Haemophilus influenzae obtained from children admitted to a hospital in Kilifi, Kenya, from 1994 to 2002.

作者信息

Scott J Anthony G, Mwarumba Salim, Ngetsa Caroline, Njenga Salome, Lowe Brett S, Slack Mary P E, Berkley James A, Mwangi Isaiah, Maitland Kathryn, English Mike, Marsh Kevin

机构信息

Wellcome Trust/Kenya Medical Research Institute, Centre for Geographic Medicine Research--Coast, P.O. Box 230, Kilifi, Kenya.

出版信息

Antimicrob Agents Chemother. 2005 Jul;49(7):3021-4. doi: 10.1128/AAC.49.7.3021-3024.2005.

Abstract

Etest susceptibilities to amoxicillin, chloramphenicol, and trimethoprim-sulfamethoxazole of 240 invasive isolates of Haemophilus influenzae cultured from children in rural Kenya were 66%, 66%, and 38%, respectively. Resistance increased markedly over 9 years and was concentrated among serotype b isolates. In Africa, the increasing cost of treating resistant infections supports economic arguments for prevention through conjugate H. influenzae type b immunization.

摘要

对从肯尼亚农村儿童中培养出的240株侵袭性流感嗜血杆菌分离株进行的Etest药敏试验显示,其对阿莫西林、氯霉素和甲氧苄啶-磺胺甲恶唑的药敏率分别为66%、66%和38%。耐药性在9年中显著增加,且集中在b型血清型分离株中。在非洲,治疗耐药感染成本的增加支持了通过b型流感嗜血杆菌结合疫苗免疫进行预防的经济学论据。

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