癫痫患者的自杀行为：对29个队列的荟萃分析研究
Suicide in the epilepsies: a meta-analytic investigation of 29 cohorts.
作者信息
Pompili Maurizio, Girardi Paolo, Ruberto Amedeo, Tatarelli Roberto
机构信息
Department of Psychiatry, Sant'Andrea Hospital, University of Rome La Sapienza, Rome, Italy.
出版信息
Epilepsy Behav. 2005 Sep;7(2):305-10. doi: 10.1016/j.yebeh.2005.05.010.
OBJECTIVES
Suicide in epilepsy is a major cause of death and is very often underestimated. We conducted a meta-analysis to compare data reported in representative studies of suicide in epilepsy with data for the general population.
METHODS
We searched the Index Medicus until 2005 through MedLine. We also searched the World Health Statistics Annual to ascertain the suicide rates in the age groups indicated in the studies on epileptic patients for specific years and country.
RESULTS
We selected 29 studies comprising 50,814 patients, 187 of whom committed suicide. Results obtained for each study were processed together to calculate the mean number of suicides per 100,000 individuals suffering from epilepsy for each year.
CONCLUSIONS
Our meta-analysis shows that suicide in patients with epilepsy is more frequent than in the general population. Nevertheless, a number of cohorts of epileptic patients had a suicide rate lower than that of the general population. Possible explanations for this heterogeneous trend and risk factors are discussed.
目的
癫痫患者自杀是主要死因，且常常被低估。我们进行了一项荟萃分析，以比较癫痫患者自杀的代表性研究报告的数据与普通人群的数据。
方法
我们通过MedLine检索了截至2005年的《医学索引》。我们还检索了《世界卫生统计年鉴》，以确定特定年份和国家的癫痫患者研究中所指明年龄组的自杀率。
结果
我们选取了29项研究，共50814例患者，其中187例自杀。对每项研究所得结果进行综合处理，以计算每年每10万癫痫患者的自杀平均数。
结论
我们的荟萃分析表明，癫痫患者自杀比普通人群更为常见。然而，一些癫痫患者队列的自杀率低于普通人群。本文讨论了这种异质性趋势和危险因素的可能解释。
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