阿弗西（Aphtheal）治疗复发性轻型阿弗他溃疡疗效的对比研究。

A comparative study of the efficacy of Aphtheal in the management of recurrent minor aphthous ulceration.

作者信息

Murray Brenda, McGuinness Niall, Biagioni Paul, Hyland Paula, Lamey Philip-John

机构信息

The Oral Science Research Centre, School of Dentistry, Queen's University Belfast, UK.

出版信息

J Oral Pathol Med. 2005 Aug;34(7):413-9. doi: 10.1111/j.1600-0714.2005.00334.x.

DOI:10.1111/j.1600-0714.2005.00334.x

PMID:16011610

Abstract

BACKGROUND

Recurrent minor aphthous ulceration (RAU) is a common condition which is multifactorial in origin.

METHODS

This study, firstly, aimed to treat the prodromal stage of RAU with Aphtheal (5% amlexanox paste) to determine if ulcer development could be prevented. A second arm of the study investigated treatment of RAU with Aphtheal once ulceration had developed. Ulcer duration, ulcer size and associated pain were measured. Both groups of subjects had previously undergone a no-treatment run-in period to establish these parameters over an untreated episode of ulceration.

RESULTS

By day 3, only 35% of the prodromal group had developed an ulcer compared with 97% of the ulcer group (P < 0.001). In the treated ulcer group only 66% had an ulcer present by day 3. Treatment at the onset of prodromal symptoms reduced the maximum ulcer size score by 84% (P < 0.01), extent of ulceration by 88% (P < 0.01), maximum pain score by 69% (P < 0.01) and extent of pain by 85% (P < 0.01) compared to no treatment.

CONCLUSION

Treatment with Aphtheal at the onset of prodromal RAU symptoms can prevent progression to ulcer development and significantly reduced symptoms if ulcers do develop.

摘要

背景

复发性轻型阿弗他溃疡（RAU）是一种常见疾病，其病因是多因素的。

方法

本研究首先旨在用阿弗他糊剂（5%氨来呫诺糊剂）治疗RAU的前驱期，以确定是否可以预防溃疡的发生。研究的另一部分调查了在溃疡形成后用阿弗他糊剂治疗RAU的情况。测量溃疡持续时间、溃疡大小和相关疼痛。两组受试者此前都经历了一个未治疗的导入期，以确定在未治疗的溃疡发作期间的这些参数。

结果

到第3天，前驱期组只有35%的人出现了溃疡，而溃疡组为97%（P<0.001）。在接受治疗的溃疡组中，到第3天只有66%的人有溃疡。与未治疗相比，在前驱症状出现时进行治疗可使最大溃疡大小评分降低84%（P<0.01），溃疡范围降低88%（P<0.01），最大疼痛评分降低69%（P<0.01），疼痛范围降低85%（P<0.01）。