子痫前期大鼠模型中瘦素及瘦素受体变化的特征分析

Characterization of changes in leptin and leptin receptors in a rat model of preeclampsia.

作者信息

Anderson Cindy M, Lopez Faye, Zhang Hai-Ying, Pavlish Kristin, Benoit Joseph N

机构信息

College of Nursing and Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks 58202, USA.

出版信息

Am J Obstet Gynecol. 2005 Jul;193(1):267-72. doi: 10.1016/j.ajog.2004.11.010.

DOI:10.1016/j.ajog.2004.11.010

PMID:16021089

Abstract

OBJECTIVE

The purpose of this study was to determine the influence of reduced uteroplacental perfusion pressure on plasma leptin and placental leptin receptor expression in rats that develop hypertension in the third trimester of pregnancy.

STUDY DESIGN

The ovarian arteries and abdominal aortae of pregnant Sprague-Dawley rats (n=9) were constricted surgically on day 14 of gestation and were matched with sham controls. Systolic blood pressure and weight were measured biweekly. Maternal plasma leptin levels, placental leptin receptor abundance, fetal number, fetal weight, and placental weight were determined.

RESULTS

Reductions in perfusion pressure induced a significant decrease in maternal plasma leptin. Maternal systolic blood pressure and leptin receptor protein abundance was increased in the experimental group. Litter size and fetal and placental weight were significantly decreased in response to reduced perfusion pressure.

CONCLUSION

Reduced uteroplacental perfusion pressure reduces litter size, fetal and placental weights, and maternal plasma leptin levels and increases placental expression of leptin receptors.

摘要