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避孕药具的递送方式。

Delivery options for contraceptives.

作者信息

Sitruk-Ware Regine

机构信息

Center for Biomedical Research, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

出版信息

Drug Discov Today. 2005 Jul 15;10(14):977-85. doi: 10.1016/S1359-6446(05)03499-9.

Abstract

Although a steady increase in contraceptive use has been observed in developed and less-developed countries, the contraceptive needs of a significant proportion of couples have not yet been met, resulting in an increase in unplanned pregnancies. Several new contraceptive products have reached the market during the past few years. Among these are new implants, a medicated intrauterine device, contraceptive vaginal rings, transdermal patches and several new regimen of combined oral contraceptives. These new or improved methods have been developed to expand the contraceptive choices available to women and men as well as to respond to the unmet need for contraceptives with long-term activity. New targets are being identified both in the ovary and the testes for a more specific non-hormonal contraception. This futuristic approach still keeps in mind the need for better access to existing contraceptive methods, as well as the discovery of new contraceptives that are simple to use, safe, reversible and inexpensive. In recent years, there has been great interest in agents that provide dual protection against pregnancy and sexually transmitted infections (STI), especially human immunodeficiency virus (HIV). A contraceptive method providing dual medical benefits might increase motivation for consistent use, thus reducing contraceptive failures and unwanted pregnancies.

摘要

尽管在发达国家和欠发达国家,避孕措施的使用呈稳步上升趋势,但仍有相当一部分夫妇的避孕需求未得到满足,导致意外怀孕的情况增多。在过去几年中,几种新型避孕产品已投放市场。其中包括新型植入剂、含药宫内节育器、避孕阴道环、透皮贴剂以及几种新型复方口服避孕药方案。研发这些新的或改进的方法,是为了扩大可供男性和女性选择的避孕方式,同时满足对具有长效作用的避孕措施的未满足需求。目前正在卵巢和睾丸中寻找新的靶点,以实现更具针对性的非激素避孕。这种前瞻性方法仍牢记需要更好地提供现有避孕方法,以及研发出使用简便、安全、可逆且价格低廉的新型避孕药。近年来,人们对能够同时预防怀孕和性传播感染(尤其是人类免疫缺陷病毒,即HIV)的药物产生了浓厚兴趣。一种具有双重医疗益处的避孕方法可能会提高持续使用的积极性,从而减少避孕失败和意外怀孕的情况。

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