亚胺培南治疗失败后，美罗培南成功治愈粘质沙雷氏菌假体感染。
Serratia marcescens prosthesis infection successfully treated with meropenem after imipenem failure.
作者信息
Lefort A, Righi S, Jauréguy F, Bégué T, Robineau M, Bouchaud O, Lortholary O
机构信息
Service de Maladies Infectieuses et Tropicales, Hôpital Necker, Université Paris V, 149 rue de Sèvres, 75743 Paris Cedex 15, France.
出版信息
J Infect. 2005 Aug;51(2):E45-7. doi: 10.1016/j.jinf.2004.08.013.
A 78-year-old woman developed an early knee-prosthesis infection due to multiresistant Serratia marcescens that was successfully treated with high-dose meropenem, after failure of a long-term therapy combining imipenem and multiple surgical interventions. Because of its lower neurotoxicity, meropenem might be preferred to imipenem/cilastatin for the treatment of osteo-articular infections due to multiresistant Gram-negative bacilli in the elderly.
一名78岁女性因多重耐药的粘质沙雷菌发生早期膝关节假体感染，在亚胺培南与多次手术干预的长期治疗失败后，高剂量美罗培南成功治愈了该感染。由于神经毒性较低，对于老年患者因多重耐药革兰氏阴性杆菌引起的骨关节炎感染，美罗培南可能比亚胺培南/西司他丁更适合用于治疗。
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