用于三维剂量测定磁共振成像的高辐射敏感性聚合物凝胶的研制。
Development of high-radiation-sensitive polymer gel for magnetic resonance imaging in three-dimensional dosimetry.
作者信息
Mori Shinichiro, Endo Masahiro, Furukawa Shigeo, Sunaoka Masayoshi, Nonaka Hiroi, Ishii Takayoshi, Ikehira Hiroo
机构信息
Department of Medical Physics, National Institute of Radiological Sciences, 4-9-1, Anagawa, Chiba, Japan, 263-8555.
出版信息
Magn Reson Imaging. 2005 Jun;23(5):691-4. doi: 10.1016/j.mri.2005.04.005.
We developed a high radiation sensitive polymer gel by modifying the amounts of the gel components and the temperature for the gel preparation. We evaluated its relaxation time linearity against dose and compared the measured dose distribution with the calculated one. For the relaxation time-dose linearity, irradiations were carried out with a linear accelerator using 6 MV photons and doses ranging from 0-5.0 Gy. The relationship between dose and R(2) value (reciprocal of T(2) relaxation time) was measured and it had good linearity over a wide range (0.3-5 Gy). The measured dose distributions were in good agreement with calculated ones. Since the present gel has higher sensitivity and it is synthesized more easily at lower cost than conventional polymer gels, we expect to see improved three-dimensional (3D) dosimetry using it.
我们通过改变凝胶成分的用量和凝胶制备温度，开发出了一种高辐射敏感性聚合物凝胶。我们评估了其弛豫时间与剂量的线性关系，并将测量得到的剂量分布与计算得到的剂量分布进行了比较。对于弛豫时间 - 剂量线性关系，使用直线加速器以6 MV光子进行辐照，剂量范围为0 - 5.0 Gy。测量了剂量与R(2)值（T(2)弛豫时间的倒数）之间的关系，在较宽范围（0.3 - 5 Gy）内具有良好的线性。测量得到的剂量分布与计算结果吻合良好。由于目前这种凝胶具有更高的敏感性，且比传统聚合物凝胶更容易以更低成本合成，我们期望看到使用它能改进三维（3D）剂量测定法。
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