Jacobi Annett M, Diamond Betty
Department of Rheumatology and Clinical Immunology, Charite University Hospital, 10117 Berlin, Germany.
J Exp Med. 2005 Aug 1;202(3):341-4. doi: 10.1084/jem.20050221.
The autoimmune disease systemic lupus erythematosus (SLE) is caused by a failure of B cell tolerance. Recent studies in mouse models of SLE have identified several distinct tolerance checkpoints that must each function appropriately to protect against disease. However, studies of B cell repertoire selection in humans are essential to understand which checkpoints are defective in human autoimmune diseases.
自身免疫性疾病系统性红斑狼疮（SLE）是由B细胞耐受性失效引起的。最近在SLE小鼠模型中的研究已经确定了几个不同的耐受性检查点，每个检查点都必须正常发挥作用以预防疾病。然而，对人类B细胞库选择的研究对于了解哪些检查点在人类自身免疫性疾病中存在缺陷至关重要。
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