Vilella Elisabet, Virgos Carmen, Murphy Michelle, Martorell Lourdes, Valero Joaquín, Simó Josep Maria, Joven Jorge, Fernández-Ballart Joan, Labad Antonio
Psychiatric University Hospital Institut Pere Mata, Unitat de Psiquiatria, Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, C/Sant Llorenç 21, 43201 Reus, Spain.
Prog Neuropsychopharmacol Biol Psychiatry. 2005 Sep;29(7):1169-74. doi: 10.1016/j.pnpbp.2005.07.001.
It has been suggested that total plasma homocysteine (tHcy) concentrations and methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms are risk factors for schizophrenia. We conducted a case-control study to investigate whether tHcy levels and MTHFR C677T and A1298C variants are associated with schizophrenia, giving special consideration to confounding factors. Logistic regression analysis showed that neither tHcy nor MTHFR polymorphisms were associated with schizophrenia. Homozygosity for MTHFR C677T was associated with higher tHcy concentrations in control and schizophrenia groups (P<0.01), which was mainly driven by the male group. The A1298C variant did not show any association with tHcy concentrations. In conclusion, these results do not confirm an independent relationship of tHcy and MTHFR genotype with risk of schizophrenia.
有人提出，血浆总同型半胱氨酸（tHcy）浓度和亚甲基四氢叶酸还原酶（MTHFR）基因多态性是精神分裂症的危险因素。我们进行了一项病例对照研究，以调查tHcy水平以及MTHFR C677T和A1298C变体是否与精神分裂症相关，并特别考虑了混杂因素。逻辑回归分析表明，tHcy和MTHFR多态性均与精神分裂症无关。MTHFR C677T纯合子与对照组和精神分裂症组中较高的tHcy浓度相关（P<0.01），这主要由男性组驱动。A1298C变体与tHcy浓度无任何关联。总之，这些结果并未证实tHcy和MTHFR基因型与精神分裂症风险之间存在独立关系。
