首次利用钯-氮杂环卡宾（NHC）催化剂实现两个烷基中心的根岸交叉偶联反应。
The first Negishi cross-coupling reaction of two alkyl centers utilizing a Pd-N-heterocyclic carbene (NHC) catalyst.
作者信息
Hadei Niloufar, Kantchev Eric Assen B, O'Brien Christopher J, Organ Michael G
机构信息
Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada.
出版信息
Org Lett. 2005 Aug 18;7(17):3805-7. doi: 10.1021/ol0514909.
PMID:16092880
Abstract
The development of an NHC-based system capable of cross-coupling sp(3)-sp(3) centers in high yield has been a long-standing challenge. This communication describes the use of a Pd-NHC catalytic system that achieves room-temperature Negishi cross-couplings of unactivated, primary bromides and alkyl organozinc reagents with a variety of functionality. [reaction: see text]
摘要
开发一种能够以高产率实现sp(3)-sp(3)中心交叉偶联的基于氮杂环卡宾（NHC）的体系一直是一项长期挑战。本通讯描述了一种钯-氮杂环卡宾催化体系的应用，该体系能在室温下实现未活化的伯溴化物与烷基有机锌试剂以及多种官能团的根岸交叉偶联反应。[反应：见正文]
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