2-Phenallyl as a versatile protecting group for the asymmetric one-pot three-component synthesis of propargylamines.
作者信息
Gommermann Nina, Knochel Paul
机构信息
Department Chemie und Biochemie, Ludwig-Maximilians-Universität München, Butenandstrasse 5-13, Haus F, D-81377 München, Germany.
出版信息
Chem Commun (Camb). 2005 Sep 7(33):4175-7. doi: 10.1039/b507810e. Epub 2005 Jul 26.
DOI:10.1039/b507810e
PMID:16100594
Abstract
2-Phenallyl was found to be a versatile protecting group of primary amines for the asymmetric one-pot three-component synthesis of propargylamines which leads to enantiomeric excess of up to 96%; it can be easily removed with a palladium(0)-catalyzed allylic substitution using 1,3-dimethylbarbituric acid as a nucleophile.
摘要
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