甲基苯丙胺急性给药对大鼠脑内Narp mRNA的影响。

Effects of acute administration of methamphetamine on Narp mRNA in rat brain.

作者信息

Fukumoto Makoto, Iwata Masaaki, Shinbori Chiko, Hazama Gen-I, Shirayama Yukihiko, Kawahara Ryuzou

机构信息

Department of Neuropsychiatry, Faculty of Medicine, Tottori Unversity, Tottori, Japan.

出版信息

Addict Biol. 2005 Sep;10(3):257-9. doi: 10.1080/13556219599222621.

DOI:10.1080/13556219599222621

PMID:16109587

Abstract

Narp (neuronal activity-regulated pentraxin) is a secreted immediate early gene product functioning as a cluster factor for the AMPA receptor subtype of glutamate receptors. This study was designed to examine the effects of acute administration of methamphetamine (MAP) on the Narp gene in rat brain using reverse transcription - polymerase chain reaction (RT-PCR). Acute administration of MAP [4.6 mg/kg, intraperitoneally (i.p.)] increased Narp mRNA in the prefrontal cortex, whereas the same treatment with MAP decreased Narp mRNA in the hippocampus. Therefore, Narp gene could be involved in the MAP-induced effects.

摘要

Narp（神经元活性调节五聚体蛋白）是一种分泌型即早基因产物，作为谷氨酸受体AMPA受体亚型的簇集因子发挥作用。本研究旨在利用逆转录-聚合酶链反应（RT-PCR）检测急性给予甲基苯丙胺（MAP）对大鼠脑内Narp基因的影响。急性腹腔注射MAP（4.6mg/kg）可增加前额叶皮质中的Narp mRNA，而相同剂量的MAP处理则可降低海马体中的Narp mRNA。因此，Narp基因可能参与了MAP诱导的效应。