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青少年双胞胎妊娠:黑人和白人胎儿生长结局的差异。

Teen twin pregnancies: differences in fetal growth outcomes among blacks and whites.

作者信息

Salihu Hamisu M, Aliyu Muktar H, Sedjro Jeanine E, Nabukera Sarah, Oluwatade Olatunji J, Alexander Greg R

机构信息

Department of Maternal and Child Health, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.

出版信息

Am J Perinatol. 2005 Aug;22(6):335-9. doi: 10.1055/s-2005-871658.

Abstract

We set out to determine the magnitude of black-white disparity in intrauterine fetal growth inhibition among twin births to teenagers (age 15 to 19) in the United States using a retrospective cohort study design. We compared the risk for low and very low birthweight, preterm and very preterm, and small for gestational age between black and white twins born to teen mothers during the period 1995 through 1998. The methodology of generalized estimating equations was used to adjust for the presence of intracluster correlation within twin pairs. A total of 29,307 individual twins were analyzed. For all fetal growth indices examined, infants born to black mothers remained disadvantaged except for preterm birth, for which the risk was comparable to that of whites (adjusted OR, 1.03; 95% confidence interval [CI] 0.95 to 1.11). The racial gap was most marked for low birthweight (OR, 1.27; 95% CI, 1.19, 1.37]) and very low birthweight (OR, 1.30; 95% CI, 1.19 to 1.42). Black twins had an equal level of elevated risk for very preterm and small for gestational age (OR, 1.17; 95% CI, 1.07 to 1.27 and OR, 1.17; 95% CI, 1.07 to 1.28, respectively). In conclusion, we found significant differences in fetal growth parameters between black and white twins born to teen gravidas. Our findings confirm similar black disadvantage reported for singletons. Current prevention strategies aimed at reducing adverse fetal outcomes among teenagers in the United States need to consider the heightened risk among neonates born to black mothers.

摘要

我们采用回顾性队列研究设计,旨在确定美国青少年(15至19岁)双胎分娩中宫内胎儿生长受限的黑白差异程度。我们比较了1995年至1998年期间青少年母亲所生黑白双胞胎之间低出生体重和极低出生体重、早产和极早产以及小于胎龄的风险。使用广义估计方程方法来调整双胞胎对中集群内相关性的存在。总共分析了29,307个个体双胞胎。对于所有检查的胎儿生长指标,黑人母亲所生婴儿除早产外仍处于劣势,早产风险与白人相当(调整后的比值比[OR],1.03;95%置信区间[CI]为0.95至1.11)。种族差距在低出生体重(OR,1.27;95%CI,1.19至1.37)和极低出生体重(OR,1.30;95%CI,1.19至1.42)方面最为明显。黑人双胞胎在极早产和小于胎龄方面的风险升高水平相当(分别为OR,1.17;95%CI,1.07至1.27和OR,1.17;95%CI,1.07至1.28)。总之,我们发现青少年孕妇所生黑白双胞胎在胎儿生长参数方面存在显著差异。我们的研究结果证实了单胎中类似的黑人劣势情况。美国目前旨在减少青少年不良胎儿结局的预防策略需要考虑黑人母亲所生新生儿的更高风险。

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