药物的胶束增溶作用。

Micellar solubilization of drugs.

作者信息

Rangel-Yagui Carlota Oliveira, Pessoa Adalberto, Tavares Leoberto Costa

机构信息

Department of Biochemical and Pharmaceutical Technology /FCF, University of São Paulo, São Paulo, Brazil.

出版信息

J Pharm Pharm Sci. 2005 Jul 8;8(2):147-65.

PMID:16124926

Abstract

PURPOSE

Micellar solubilization is a powerful alternative for dissolving hydrophobic drugs in aqueous environments. In this work, we provide an insight into this subject.

METHODS

A concise review of surfactants and micelles applications in pharmacy was carried out.

RESULTS

Initially, a description of surfactants and aqueous micellar systems is presented. Following, an extensive review on micellar drug solubilization, including both the principles involved on this phenomenon and the work already done regarding solubilization of drugs by micelles is presented. The application of micelles in drug delivery, in order to minimize drug degradation and loss, to prevent harmful side effects, and to increase drug bioavailability, is also presented. Special emphasis is given to the more recent use of polymeric micelles. Finally, we briefly discuss the importance of surfactants and micelles as biological systems models as well as its application in micellar catalysis.

CONCLUSIONS

As can be seen from the review presented, the use of micelles in pharmacy is an important tool that finds numerous applications.

摘要

目的

胶束增溶是在水性环境中溶解疏水药物的一种有效替代方法。在本研究中，我们对这一主题进行了深入探讨。

方法

对表面活性剂和胶束在药学中的应用进行了简要综述。

结果

首先，介绍了表面活性剂和水性胶束体系。随后，对胶束药物增溶进行了广泛综述，包括这一现象所涉及的原理以及关于胶束增溶药物的已有研究。还介绍了胶束在药物递送中的应用，以尽量减少药物降解和损失、防止有害副作用并提高药物生物利用度。特别强调了聚合物胶束的最新应用。最后，我们简要讨论了表面活性剂和胶束作为生物系统模型的重要性及其在胶束催化中的应用。