CD97（柄部）和CD55作为胃癌患者预后和治疗分子标志物的作用。
Role of CD97(stalk) and CD55 as molecular markers for prognosis and therapy of gastric carcinoma patients.
作者信息
Liu Yong, Chen Li, Peng Shu-You, Chen Zhou-Xun, Hoang-Vu C
机构信息
Department of Surgery, Second Affiliated Hospital, School of Medicine, Yangzhou University, Yangzhou 225001, China.
出版信息
J Zhejiang Univ Sci B. 2005 Sep;6(9):913-8. doi: 10.1631/jzus.2005.B0913.
OBJECTIVES
To explore the mechanism of development and aggressiveness in gastric carcinomas by investigating the expression and role of CD97 and its cellular ligand CD55 in gastric carcinomas.
METHODS
Tumor and corresponding normal mucosal tissue, collected from 39 gastric carcinoma patients, were examined by immunohistochemistry and RT-PCR for the expression of CD97 and CD55.
RESULTS
CD97(stalk) was strongly stained on scattered tumor cells or small tumor cell clusters at the invasion front of gastric carcinomas. The expression of CD97(stalk) was frequently observed in tumors of stage I and T1 gastric carcinoma patients. The expression of CD97(stalk) between Stage I and Stage II, III, IV specimens showed significant difference (P<0.05), between T1 and T2, T3, T4 specimens also showed significant difference (P<0.05). Specimens with tumor invasion depth limited in mucosa of T1 specimens showed higher positive CD55 expression than specimens with the same tumor invasion depth in T2, T3, T4 specimens, the expression of CD55 between T1 and T2, T3, T4 specimens was significantly different (P<0.05). There was strong correlation between the distribution patterns of CD97(stalk) and CD55 on tumor tissues (r=0.73, P<0.05). Signet ring cell carcinomas frequently contained strong CD97(stalk) and CD55-staining.
CONCLUSIONS
Our results suggest that CD97(stalk) is probably involved in the growth, invasion and aggressiveness of gastric carcinomas by binding its cellular ligand CD55. CD97(stalk) and CD55 could be useful as molecular markers for prognosis and therapy of gastric carcinoma patients.
目的
通过研究CD97及其细胞配体CD55在胃癌中的表达及作用，探讨胃癌发生发展及侵袭性的机制。
方法
收集39例胃癌患者的肿瘤组织及相应正常黏膜组织，采用免疫组织化学和逆转录聚合酶链反应检测CD97和CD55的表达。
结果
CD97（柄部）在胃癌侵袭前沿的散在肿瘤细胞或小肿瘤细胞簇上呈强染色。CD97（柄部）的表达在Ⅰ期和T1期胃癌患者的肿瘤中常见。Ⅰ期与Ⅱ、Ⅲ、Ⅳ期标本中CD97（柄部）的表达有显著差异（P<0.05），T1与T2、T3、T4期标本中也有显著差异（P<0.05）。肿瘤浸润深度局限于T1期标本黏膜层的标本，其CD55阳性表达高于T2、T3、T4期相同肿瘤浸润深度的标本，T1与T2、T3、T4期标本中CD55的表达有显著差异（P<0.05）。肿瘤组织上CD97（柄部）与CD55的分布模式之间存在强相关性（r=0.73，P<0.05）。印戒细胞癌常含有强CD97（柄部）和CD55染色。
结论
我们的结果表明，CD97（柄部）可能通过结合其细胞配体CD55参与胃癌的生长、侵袭和侵袭性。CD97（柄部）和CD55可作为胃癌患者预后和治疗的分子标志物。
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