呼吸系统的衰老：对肺功能测试的影响及对运动的适应性

Aging of the respiratory system: impact on pulmonary function tests and adaptation to exertion.

作者信息

Janssens Jean-Paul

机构信息

Outpatient Section of the Division of Pulmonary Diseases, Geneva University Hospital, 1211 Geneva 14, Switzerland.

出版信息

Clin Chest Med. 2005 Sep;26(3):469-84, vi-vii. doi: 10.1016/j.ccm.2005.05.004.

DOI:10.1016/j.ccm.2005.05.004

PMID:16140139

Abstract

Normal aging of the respiratory system is associated with a decrease in static elastic recoil of the lung, in respiratory muscle performance, and in compliance of the chest wall and respiratory system, resulting in increased work of breathing compared with younger subjects and a diminished respiratory reserve in cases of acute illness, such as heart failure, infection, or airway obstruction. In spite of these changes, the respiratory system remains capable of maintaining adequate gas exchange at rest and during exertion during the entire lifespan, with only a slight decrease in Pa(O2) and no significant change in Pa(CO2).

摘要

呼吸系统的正常老化与肺的静态弹性回缩力降低、呼吸肌功能下降以及胸壁和呼吸系统顺应性降低有关，与年轻受试者相比，这会导致呼吸功增加，并且在患有急性疾病（如心力衰竭、感染或气道阻塞）时呼吸储备减少。尽管存在这些变化，但呼吸系统在整个生命周期内仍能够在休息和运动期间维持足够的气体交换，仅动脉血氧分压（Pa(O2)）略有下降，而动脉血二氧化碳分压（Pa(CO2)）无显著变化。