Schellenberger Eyk
Institut für Radiologie, Charité-Universitätsmedizin, Berlin.
Z Med Phys. 2005;15(3):187-91. doi: 10.1078/0939-3889-00269.
Optical imaging in the form of near infrared fluorescence and bioluminescence has proven useful for a wide range of applications in the field of molecular imaging. Both techniques provide a high sensitivity (in the nanomolar range), which is of particular importance for molecular imaging. Imaging with near infrared fluorescence is especially cost-effective and can be performed, in contrast to radioactivity-based methods, with fluorescence dyes that remain stable for months. The most important advantage of bioluminescence, in turn, is the lack of background signal. Although molecular imaging with these techniques is still in the experimental phase, an application of near infrared fluorescence is already foreseeable for the imaging of superficial structures.
近红外荧光和生物发光形式的光学成像已被证明在分子成像领域的广泛应用中很有用。这两种技术都具有高灵敏度(在纳摩尔范围内),这对于分子成像尤为重要。与基于放射性的方法相比,近红外荧光成像特别具有成本效益,并且可以使用能稳定数月的荧光染料进行。反过来,生物发光的最重要优势是缺乏背景信号。尽管使用这些技术的分子成像仍处于实验阶段,但近红外荧光在浅表结构成像中的应用已经可以预见。