Turner M L, Watson H G, Russell L, Langlands K, Ludlam C A, Parker A C
Department of Haematology, Royal Infirmary of Edinburgh, UK.
Bone Marrow Transplant. 1992 May;9(5):387-9.
A 26-year-old HIV positive severe haemophiliac developed Burkitt-type acute lymphoblastic leukaemia with intracranial involvement. He underwent standard combination therapy, and entered complete remission. Syngeneic bone marrow transplantation (BMT) was undertaken; the donor was also HIV positive. The patient died 18 months from transplant of isolated intracranial relapse, with no evidence of systemic relapse. Unlike other types of non-Hodgkin's lymphoma, Burkitt's type occurs in HIV positive patients with relatively normal CD4 cell counts. Remission can be achieved using intensive chemotherapy, and since these patients may otherwise have a reasonable life expectancy, BMT may be appropriate.
一名26岁的HIV阳性重度血友病患者患上了伴有颅内受累的伯基特型急性淋巴细胞白血病。他接受了标准的联合治疗，并进入完全缓解期。进行了同基因骨髓移植（BMT）；供体也是HIV阳性。患者在移植后18个月死于孤立性颅内复发，无全身复发迹象。与其他类型的非霍奇金淋巴瘤不同，伯基特型发生在CD4细胞计数相对正常的HIV阳性患者中。使用强化化疗可实现缓解，而且由于这些患者在其他方面可能有合理的预期寿命，骨髓移植可能是合适的。
