N-苯甲酰基-d-苯丙氨酸对新生链脲佐菌素糖尿病大鼠肝脏脂质谱的影响。
Effect of N-benzoyl-d-phenylalanine on lipid profile in liver of neonatal streptozotocin diabetic rats.
作者信息
Pari Leelavinothan, Ashokkumar Natarajan
机构信息
Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar, Tamil Nadu - 608 002, India.
出版信息
Fundam Clin Pharmacol. 2005 Oct;19(5):563-8. doi: 10.1111/j.1472-8206.2005.00366.x.
The effect of N-benzoyl-d-phenylalanine (NBDP) and metformin combination treatment on liver lipids and lipid peroxidation markers was studied in neonatal streptozotocin (nSTZ) diabetic rats. Oral administration of NBDP (50, 100 and 200 mg/kg body weight) and metformin (500 mg/kg body weight) for 6 weeks significantly reduced the elevated blood glucose, liver cholesterol, triglycerides, free fatty acids and phospholipids. The combination treatment also caused a significant decrease in hepatic hydroxymethyl glutaryl-coenzyme A reductase, Thiobarbituric Acid Reactive Substances (TBARS) and significant increase in reduced glutathione levels. The results show that NBDP and metformin improve the hepatic lipid profile and antioxidant status in nSTZ diabetic rats. Combination treatment was more effective than either drug alone.
在新生链脲佐菌素（nSTZ）诱导的糖尿病大鼠中，研究了N-苯甲酰基-d-苯丙氨酸（NBDP）与二甲双胍联合治疗对肝脏脂质和脂质过氧化标志物的影响。口服给予NBDP（50、100和200mg/kg体重）和二甲双胍（500mg/kg体重）6周，可显著降低升高的血糖、肝脏胆固醇、甘油三酯、游离脂肪酸和磷脂水平。联合治疗还使肝脏羟甲基戊二酰辅酶A还原酶、硫代巴比妥酸反应性物质（TBARS）显著降低，还原型谷胱甘肽水平显著升高。结果表明，NBDP和二甲双胍可改善nSTZ糖尿病大鼠的肝脏脂质谱和抗氧化状态。联合治疗比单独使用任何一种药物都更有效。
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