Bement William M
Department of Zoology, University of Wisconsin-Madison, 53708, USA.
Chem Biol. 2005 Sep;12(9):953-4. doi: 10.1016/j.chembiol.2005.08.012.
The target of locostatin, a small-molecule inhibitor of cell movement, has been identified as RKIP, a Raf-1 kinase modulator [1]. In addition to advancing our understanding of cell locomotion, this work represents a major landmark in the development of chemical genetics.