使用 Aerodiol 对绝经后女性脑血流量的影响。
Effect of Aerodiol administration on cerebral blood flow volume in postmenopausal women.
作者信息
Acar Murat, Cevrioglu Arif Serhan, Haktanir Alpay, Demirel Reha, Albayrak Ramazan, Degirmenci Bumin, Yucel Aylin, Akyol Ahmet Melih
机构信息
Afyon Kocatepe University Faculty of Medicine, Department of Radiology, Kirmizi Hastane, Turkey.
出版信息
Maturitas. 2005 Oct 16;52(2):127-33. doi: 10.1016/j.maturitas.2005.01.006.
OBJECTIVE
The aim of the study was to evaluate the acute effect of the intranasal 17beta-estradiol (Aerodiol, Servier, Chambray-les-Tours, France) administration on cerebral blood flow (CBF) volume.
METHODS
Eighteen healthy women who had been natural postmenopausal for at least 1 year were enrolled in the study. We conducted an experimental, randomized, placebo-controlled, crossover, double-blinded study of the acute effect of 17beta-estradiol on the internal carotid artery (ICA), vertebral artery (VA) and, CBF volume using color duplex sonography.
RESULTS
There were significant increases in the ICA, VA flow volumes and CBF volume after 17beta-estradiol administration compared to placebo measurements. However, there was no statistically significant difference in flow velocities or pulsatility indices.
CONCLUSION
Nasal 17beta-estradiol administration in postmenopausal women causes significant increases in CBF volume due to its vasodilatatory effect on ICA and VA.
目的
本研究旨在评估经鼻给予17β-雌二醇（法国施维雅公司生产的Aerodiol，位于尚布雷莱图尔）对脑血流量（CBF）的急性影响。
方法
18名自然绝经至少1年的健康女性参与了本研究。我们使用彩色双功能超声对17β-雌二醇对颈内动脉（ICA）、椎动脉（VA）及CBF的急性影响进行了一项实验性、随机、安慰剂对照、交叉、双盲研究。
结果
与安慰剂测量结果相比，给予17β-雌二醇后，ICA、VA血流量及CBF均显著增加。然而，血流速度或搏动指数无统计学显著差异。
结论
绝经后女性经鼻给予17β-雌二醇因其对ICA和VA的血管舒张作用而导致CBF显著增加。
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