Hanekamp B B, Zijlstra J G, Tulleken J E, Ligtenberg J J M, van der Werf T S, Hofstra L S
Intensive and Respiratory Care, Groningen University Medical Centre, Groningen, the Netherlands.
Neth J Med. 2005 Sep;63(8):316-8.
Newer, more selective, antidepressant agents are increasingly being used as first-line treatment. However, clinical experience in patients after a deliberate overdose is limited. We present a case of venlafaxine intoxication complicated by a late rise in creatine kinase, seizures and serotonin syndrome. Rhabdomyolysis prolonged the hospital stay in our patient but had no other serious consequences. Physicians should be aware of this late phenomenon in patients with venlafaxine poisoning.
更新的、更具选择性的抗抑郁药正越来越多地被用作一线治疗药物。然而,对于故意过量服药患者的临床经验有限。我们报告一例文拉法辛中毒病例,该病例并发肌酸激酶延迟升高、癫痫发作和5-羟色胺综合征。横纹肌溶解延长了我们这位患者的住院时间,但未造成其他严重后果。医生应了解文拉法辛中毒患者的这种迟发现象。