CD20：自身免疫性疾病免疫治疗的靶抗原。

CD20: a target antigen for immunotherapy of autoimmune diseases.

作者信息

Perosa Federico, Favoino Elvira, Caragnano Maria Antonietta, Prete Marcella, Dammacco Franco

机构信息

Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy.

出版信息

Autoimmun Rev. 2005 Nov;4(8):526-31. doi: 10.1016/j.autrev.2005.04.004.

DOI:10.1016/j.autrev.2005.04.004

PMID:16214090

Abstract

This article reviews the role of CD20 antigen in B cell function and the effectiveness and limits of passive immunotherapy with anti-CD20 monoclonal antibody (Rituximab) in the treatment of autoimmune (or immune-mediated) diseases. Active immunotherapy is a more feasible way to control these chronic diseases. A peptide that mimics the CD20 epitope recognized by Rituximab is employed to stimulate the host immune response against CD20.

摘要

本文综述了CD20抗原在B细胞功能中的作用，以及抗CD20单克隆抗体（利妥昔单抗）被动免疫疗法在自身免疫性（或免疫介导性）疾病治疗中的有效性和局限性。主动免疫疗法是控制这些慢性疾病的一种更可行的方法。一种模拟利妥昔单抗识别的CD20表位的肽被用于刺激宿主针对CD20的免疫反应。