发育过程中的G蛋白。

G proteins in development.

作者信息

Malbon Craig C

机构信息

Department of Pharmacology, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, New York 11794-8651, USA.

出版信息

Nat Rev Mol Cell Biol. 2005 Sep;6(9):689-701. doi: 10.1038/nrm1716.

DOI:10.1038/nrm1716

PMID:16231420

Abstract

The focus of developmental biologists has expanded from the analysis of gene expression to include the analysis of cell signalling. Heterotrimeric G proteins (G proteins) mediate signalling from a superfamily of heptahelical receptors (G-protein-coupled receptors) to a smaller number of effector units that include adenylyl cyclases, phospholipase C and various ion channels. The convergence of developmental biology with cell signalling has now revealed overlaps in which G proteins mediate complex pathways in embryonic development.

摘要

发育生物学家的研究重点已从基因表达分析扩展到包括细胞信号传导分析。异源三聚体G蛋白（G蛋白）介导从七螺旋受体超家族（G蛋白偶联受体）到数量较少的效应器单元的信号传导，这些效应器单元包括腺苷酸环化酶、磷脂酶C和各种离子通道。发育生物学与细胞信号传导的融合现已揭示出重叠之处，即G蛋白在胚胎发育中介导复杂的信号通路。