通过锆氢化-环化反应从N-烯丙基恶唑烷立体选择性合成吡咯烷。

Stereoselective synthesis of pyrrolidines from N-allyl oxazolidines via hydrozirconation-cyclization.

作者信息

Vasse Jean-Luc, Joosten Antoine, Denhez Clément, Szymoniak Jan

机构信息

Réactions Sélectives et Applications, CNRS (UMR 6519) and Université de Reims, France.

出版信息

Org Lett. 2005 Oct 27;7(22):4887-9. doi: 10.1021/ol0517776.

DOI:10.1021/ol0517776

PMID:16235914

Abstract

[reaction: see text] A new diastereoselective synthesis of pyrrolidines from readily available chiral N-allyl oxazolidines is presented. The construction of the pyrrolidine ring is achieved via a tandem hydrozirconation-stereoselective Lewis acid mediated cyclization sequence.

摘要

[反应：见正文] 报道了一种从容易获得的手性N-烯丙基恶唑烷出发的吡咯烷新的非对映选择性合成方法。吡咯烷环的构建是通过串联锆氢化-立体选择性路易斯酸介导的环化序列实现的。