载脂蛋白B：一种具有临床重要性的载脂蛋白，它组装致动脉粥样硬化脂蛋白并促进动脉粥样硬化的发展。
Apolipoprotein B: a clinically important apolipoprotein which assembles atherogenic lipoproteins and promotes the development of atherosclerosis.
作者信息
Olofsson S-O, Borèn J
机构信息
Wallenberg Laboratory for Cardiovascular Research, Göteborg University, Sahlgrenska University Hospital, Göteborg, Sweden.
出版信息
J Intern Med. 2005 Nov;258(5):395-410. doi: 10.1111/j.1365-2796.2005.01556.x.
Apolipoprotein (apo) B exists in two forms apoB100 and apoB48. ApoB100 is present on very low-density lipoproteins (VLDL), intermediate density lipoproteins (IDL) and LDL. ApoB100 assembles VLDL particles in the liver. This process starts by the formation of a pre-VLDL, which is retained in the cell unless converted to the triglyceride-poor VLDL2. VLDL2 is secreted or converted to VLDL1 by a bulk lipidation in the Golgi apparatus. ApoB100 has a central role in the development of atherosclerosis. Two proteoglycan-binding sequences in apoB100 have been identified, which are important for retaining the lipoprotein in the intima of the artery. Retention is essential for the development of the atherosclerotic lesion.
载脂蛋白（apo）B 以两种形式存在，即 apoB100 和 apoB48。apoB100 存在于极低密度脂蛋白（VLDL）、中间密度脂蛋白（IDL）和低密度脂蛋白（LDL）上。apoB100 在肝脏中组装 VLDL 颗粒。这个过程始于前 VLDL 的形成，前 VLDL 会保留在细胞内，除非转化为甘油三酯含量低的 VLDL2。VLDL2 通过高尔基体中的大量脂化作用被分泌或转化为 VLDL1。apoB100 在动脉粥样硬化的发展中起核心作用。已在 apoB100 中鉴定出两个蛋白聚糖结合序列，它们对于将脂蛋白保留在动脉内膜中很重要。保留对于动脉粥样硬化病变的发展至关重要。
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