碱基配对对鸟嘌呤氧化电位影响的直接实验观察。

Direct experimental observation of the effect of the base pairing on the oxidation potential of Guanine.

作者信息

Caruso Tonino, Carotenuto Maurizio, Vasca Ermanno, Peluso Andrea

机构信息

Dipartimento di Chimica, Università di Salerno, via Salvador Allende, 43 Baronissi, Italy 84081.

出版信息

J Am Chem Soc. 2005 Nov 2;127(43):15040-1. doi: 10.1021/ja055130s.

DOI:10.1021/ja055130s

PMID:16248639

Abstract

The effect of complementary base pairing on the oxidation potential of a guanosine derivative has been determined by cyclic and differential pulse voltammetry in CHCl3. The formation of the Watson-Crick H-bonded complex lowers the oxidation potential of the free molecule by 0.34 V, which compares well with the value obtained by DFT/B3LYP/6-311++g** computations.

摘要

通过在CHCl₃中进行循环伏安法和差分脉冲伏安法，已确定互补碱基配对对鸟苷衍生物氧化电位的影响。沃森-克里克氢键复合物的形成使游离分子的氧化电位降低了0.34 V，这与通过DFT/B3LYP/6-311++g**计算获得的值相当。