头颈癌患者的组织电特性

Tissue electric properties in head and neck cancer patients.

作者信息

De Luis D A, Aller R, Izaola O, Terroba M C, Cabezas G, Cuellar L

机构信息

Institute of Endocrinology and Nutrition, Unidad de Apoyo a la Investigación, H Universitario Río Hortega, Sv. Digestive, H Valladolid, Spain.

出版信息

Ann Nutr Metab. 2006;50(1):7-10. doi: 10.1159/000089484. Epub 2005 Nov 2.

DOI:10.1159/000089484

PMID:16272813

Abstract

BACKGROUND

The phase angle of the impedance vector was lower because of a decreased Xc component in hemodialysis patients with poorer prognosis, patients with hemodynamic instability, and in critically ill patients. The phase angle is easy to obtain. The aim of our study was to investigate in a case-control study the utility of phase angle and other impedance parameters in a population of male patients with head and neck cancer.

MATERIAL AND METHODS

A case-control study was designed. A population of 67 ambulatory post-surgical male patients was enrolled with the following inclusion criteria: oral and/or laryngeal cancer confirmed by biopsy, without a recent loss weight (<5% during previous 3 months) and signed informed consent. As reference group, we selected 70 male subjects from the same geographic region and matched by age, which were selected from a database of healthy people of our hospital. Basal blood sampling was performed for determinations of blood chemistry. Weight, height, body mass index and tetrapolar body electrical bioimpedance were performed in both groups.

RESULTS

A total of 67 head and neck cancer male patients were enrolled, mean age was 58.49 +/- 14.54 years, weight 73.32 +/- 11.4 kg and BMI 28.53 +/- 3.5. A total of 70 controls subjects were studied, mean age was 62.33 +/- 12.4 years. Weight 64.31 +/- 8.38 kg and BMI 24.33 +/- 3.2 were significantly lower than in cancer patients (p < 0.05). Renal function and blood sodium levels were similar in both groups. Anthropometric evaluation in cancer patients showed a mean fat mass lower than control patients (13.9 +/- 6.1 vs. 12.1 +/- 6.1 kg; p < 0.05). In control patients, fat-free mass was higher than in cancer patients (58.7 +/- 8.2 vs. 51.23 +/- 8.4 kg; p < 0.05). In cancer patients, reactance (62.3 +/- 17.2 vs. 56.6 +/- 15.1 ohm; p < 0.05) and phase angle (8.02 +/- 1.3 vs. 6.9 +/- 1.5 degrees ; p < 0.05) were lower than in control patients.

CONCLUSION

Impedance in male head and neck cancer patients were characterized by a reduced reactance and phase angle. These early altered tissue electric properties appeared with a normal weight and body mass index.

摘要

背景

在预后较差的血液透析患者、血流动力学不稳定的患者以及危重症患者中，由于电抗（Xc）成分降低，阻抗向量的相角较低。相角易于获取。我们研究的目的是在一项病例对照研究中，调查相角和其他阻抗参数在男性头颈癌患者群体中的效用。

材料与方法

设计了一项病例对照研究。纳入了67例门诊术后男性患者，其纳入标准如下：经活检确诊为口腔和/或喉癌，近期无体重减轻（前3个月内体重减轻<5%）且签署知情同意书。作为参照组，我们从同一地理区域选取了70名男性受试者，并按年龄进行匹配，这些受试者选自我院健康人群数据库。采集基础血样以测定血液生化指标。对两组患者均进行了体重、身高、体重指数和四极体电阻抗测量。

结果

共纳入67例男性头颈癌患者，平均年龄为58.49±14.54岁，体重73.32±11.4 kg，体重指数28.53±3.5。共研究了70名对照受试者，平均年龄为62.33±12.4岁。体重64.31±8.38 kg，体重指数24.33±3.2，均显著低于癌症患者（p<0.05）。两组的肾功能和血钠水平相似。癌症患者的人体测量评估显示，平均脂肪量低于对照患者（13.9±6.1 vs. 12.1±6.1 kg；p<0.05）。在对照患者中，去脂体重高于癌症患者（58.7±8.2 vs. 51.23±8.4 kg；p<0.05）。癌症患者的电抗（62.3±17.2 vs. 56.6±15.1欧姆；p<0.05）和相角（8.02±1.3 vs. 6.9±1.5度；p<0.05）低于对照患者。